Previous studies have reported incidence of hemoglobin E (Hb E) among some populations of West Bengal. In the present study an endogamous caste of West Bengal, namely the Paundra Kshatriya was examined. The frequency of Hb E gene in this population (0.0375) is more or less similar with the Garo (0.0476), Rabha (0.0611) and Lepcha (0.0209) of the state, among whom selective pressure of malaria is not operating.